Whole genome re-sequencing (WGR) compares the genomes of different individuals and populations to reference genomes to find variations in their genomes. These variations in the genome include single nucleotide polymorphisms (SNPs) and insertions-deletions (InDels). Whole genome re-sequencing can also detect larger genetic rearrangements, such as translocations, inversions, and copy number variations.

This method is used to find important traits and markers for inherited disorders, cancer mutations, disease outbreaks, and molecular breeding, as well as for improving agriculture and conservation efforts.